Looking for a potent GH release that doesn’t involve needles? Ibutamoren (mk-677) may just fit the bill…
The benefits of Growth Hormone on metabolism and lean body mass are undeniable. I also go to great lengths pointing out that I don’t think GH is much of a muscle builder per se, and that its ultimate benefit comes down to controlling, or rather off-setting, the detrimental effects of insulin on body composition, when it comes to excessive fat gain. Insulin and IGF-1 are amazing at increasing protein synthesis, no doubt, but the real benefits after extended trials of anything that increases GH levels seem to come more in the way of increased leanness, and decreased fat storage.
Ibutamoren, MK-677 is often referred to as part of the SARM family, although strictly speaking this is incorrect. Ibutamoren is not a selective androgen receptor modulator but is a compound known as a secretagogue.
Ibutamoren is taken orally and can help you increase muscle mass, boost muscle size, and improve your strength in training too (which will obviously also lead to better gains). It can also help you lose more body fat during a cutting diet or a body recomposition phase.
MK-677 makes the body increase the amount of growth hormone it produces, which has many ancillary effects, most of which are related to muscle growth and increased bone density. In medical fields, it was developed to treat frailty in the elderly. In short, the main benefits of ibutamoren are:
- Increases IGF-1 and growth hormone serum levels
- Promotes lean muscle mass gain
- Increases fat oxidation
- Boosts recovery and healing including bones, tendons, and ligaments
- Tightens the skin
- Improves sleep quality
In addition to increases in muscle tissue and a leaner physique, studies suggest that Ibutamoren can produce significant anti-ageing effects, as well as improved bone density and more rapid recovery times.
A single tablet taken daily is designed to release wave after wave of naturally secreted growth hormones.
6 BENEFITS OF MK-677
#1 Muscle retention: Ibutamoren has been shown to reverse protein loss and associated muscle wasting - good news for bodybuilders who want to diet to lose fat but hate the idea of sacrificing hard-earned muscle mass. Muscle gain made with HGH is longer-lasting, so any gains you make on Ibutamoren are likely to last longer, too.
#2 Muscle gain: Ibutamoren MK-677 doesn’t just help you hang on to muscle mass in the face of a possibly catabolic environment. It can also boost the growth of new muscle cells. It does this by stimulating secretion of GH and IGF-1 which increase protein synthesis. That means hefty gains if you’re already eating and training right.
#3 Bone strength: All that extra growth hormone will mean better bone density in the short term and the long term, which is good news for your gains now, and for your health once you get older. Look better and stay more active in later life? Yes please.
#4 Sleep and recovery: Ibutamoren may improve the amount of REM sleep you get (and the quality of your sleep), which means better recovery between training and more time in that muscle-gaining anabolic state. Better sleep also means more energy for training the next day, plus less hunger and fewer cravings.
#5 Nootropics: Ibutamoren is also popular with the nootropic crowd because it is thought to have brain benefits. This means better wellbeing and mood, with more motivation and focus on training and cardio.
#6 Fat loss: Using Ibutamoren may encourage your body to use stored fat for energy, and remember that it protects muscle at the same time. This means true lean gains: fat loss with muscle gain for that full, pumped, shredded look.
HOW DOES MK-677 WORK?
Ibutamoren is an orally taken drug which once ingested tricks the pituitary gland into working overdrive. The massive boost in GH or growth hormone is what makes it so interesting to the bodybuilding world. Combined with the appropriate diet and exercise regimen, an introduction of Ibutamoren can cause impressive muscle growth alongside much improved fat loss.
The most common side-effects experienced with Ibutamoren include slight lethargy, some experience increased appetite, although this isn’t always a negative side-effect for those who need some help gaining weight/bulking.
Although rare, some users have reported headaches and nausea, which would appear to increase in prominence at higher doses.
MK-677 IS SAFE FOR WOMEN
Ibutamoren is fine to use for both men and women as it doesn’t affect the amount of testosterone or estrogen the body produces. This means that there is zero-risk of specific hormonal imbalances and unwanted side-effects like puffy nipples, heightened aggression or hair loss.
HOW TO USE MK-677 & DOSAGE
Most users will tend to use 20-25mg per day although MK-677 is still very effective at doses as low as 10mg, which can be useful for people who feel tired or hungry at higher doses. Start at 10mg for the first week to assess how you feel if it’s your first time using the compound.
Ibutamoren MK-677 can be taken by itself or as part of a stack with other compounds. It has a long half-life of 24 hours which means you can take your daily dose in one go - but it does spike growth hormone, so you might like to split your dose to avoid tiredness after the GH spike.
The benefits and efficacy of MK-677 increases with longer-term use, so the recommended cycle length is 3-6 months for optimum results.
MK-677 is often stacked with Cardarine, LGD-033 and RAD-140 but it is an exceptionally versatile compound and can be stacked with anything else.
Stacking Ibutamoren with Cardarine (another compound commonly mistaken for a SARM), or Ligandrol, will increase lean mass and decrease body fat. Stacking it with Testolone RAD-140 is a winning combination for rapid muscle mass gain and fat loss.
But with an orally active version like Ibutamoren, a single dose can increase benefits throughout the entire day.
And the results from the studies I’ve seen, show promising results.
To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677. Each period involved bedtime administration of the drug for 7 consecutive days. At the end of each period, plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) were measured at 0745 h, and 24-h profiles of plasma GH and cortisol were obtained at 15-min intervals together with the 24-h urinary excretion of free cortisol. Profiles of plasma free cortisol were calculated at hourly intervals. The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses. Plasma IGF-I levels were increased in a dose-dependent manner, whereas IGFBP-3 levels were increased only with the highest dosage. There was a positive relationship between GH pulse frequency and IGF-I increase. Except for an advance in the nocturnal nadir and in the morning elevation, MK-677 had no effect on cortisol profiles. In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions. The present data suggest that the use of MK-677 for the treatment of relative somatotropic deficiency, particularly in older adults compromised by such deficiency, deserves further investigation.
And a quick note about the cortisol effects… A lot of these peptides increase Cortisol, which is definitely not wanted during the peak of GH release, if physical transformation is a goal. Many of these also increase Prolactin, which can cause a lot of other side-effects. So an orally active GH releaser that doesn’t increase Cortisol is definitely going to be a game changer.
Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure
We conclude that 2-month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGF-I, and IGF-binding protein-3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate. Further studies are needed to evaluate whether a higher dose of MK-677 or a more prolonged treatment period can promote a reduction in body fat.
Another quick point. IGF-BP3 increases are a good thing. In some instances, we see a binding protein and think of SHBG, Sex Hormone Binding Globulin, which arguably makes Testosterone less effective. In this instance, however, the binding protien IGF-BP3 is needed to carry the IGF-1 into the cell and activate the receptor. So anything that increases IGF-1 AND also increases BP3 is a definite benefit.
10MG PER CAPSULE
1 PER DAY MINIMUM, 3 MAXIMUM